Usefulness of skin tests in penicillin-allergic patients after cephalosporins challenge
نویسندگان
چکیده
Background Subjects with a history of documented penicillin allergy but with negative skin test results for cephalosporins, can tolerate subsequent challenge doses of cephalosporin without an allergic reaction. [1]. In immediate reactions to betalactams (BL), in some instances, specificity was mainly directed to the BL inducing the reaction, but in other cases specificity was mainly directed to another structure, probably related with previous BL exposure [2].
منابع مشابه
Evaluation of immediate allergic reactions to cephalosporins in non-penicillin-allergic patients.
BACKGROUND Cephalosporins can induce severe or life-threatening IgE-mediated reactions in some individuals. In this study, we wish to describe a group of non-penicillin-allergic patients who were evaluated for immediate allergic reactions to cephalosporins. METHODS The patients were assessed by skin tests with the culprit cephalosporin as well as with other cephalosporins and penicillins. If ...
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Background Diagnostic workup of penicillin allergy comprises skin testing with penicillins, and patients are deemed allergic if skin test is positive. However, the literature suggests that skin test-positive patients may be challenge-negative, indicating that the skin test may be falsely positive. Objective To investigate real-time histamine release from a positive intracutaneous test induced...
متن کاملImmediate allergic reactions to cephalosporins and penicillins and their cross-reactivity in children.
Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and thei...
متن کاملDiagnosing hypersensitivity reactions to cephalosporins in children.
OBJECTIVES The goals were to evaluate the usefulness of skin tests, patch tests, serum specific IgE assays, and challenges in diagnosing hypersensitivity reactions to cephalosporins and to clarify the pathogenic mechanism of such reactions. METHODS Children with immediate manifestations (within 1 hour) underwent immediate-reading skin tests with penicillin reagents and any suspect cephalospor...
متن کاملImmediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins.
BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed. OBJECTIVE To evaluate the in vitro IgE response and cross-reactivity to betalactams in patients with ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2014